Journal of Current Research in Food Science
2024, Vol. 5, Issue 2, Part B
Multiple factors influence skin cancer development: A comprehensive review
Author(s): Tisha Punjabi, Vaishnavi Singh, Jyoti Rani and Pavneet Kaur
Abstract: Any human malignancies have mutations in the tumor suppressor gene p53. They are typically prevalent in actinic keratoses (AKs) and over 90% of squamous cell carcinomas (SCCs) have them. In the US and many other nations, skin cancer is becoming more common and killing more people. Many groups are considering public and professional health programs as a potential solution due to concerns that stratospheric ozone depletion is exacerbating the issue. Since melanoma mortality is directly correlated with the degree of tumor invasion at the time of removal, early diagnosis can mitigate the issue in the short run. This is the element that can be altered in an early detection education program. There is little doubt that exposure to sunlight increases the chance of developing skin cancer, both melanoma and nonmelanoma types. This is the part of the equation that combines exposure to environmental risk factors with constitutional predisposition. Light-skinned, easily sunburned people and those who are exposed to the sun the most whether for work-related or socially purposeful reasons are more likely to develop skin cancer. Moreover, non-melanoma skin malignancies mostly develop on areas exposed to sunlight. The incidence of skin cancer could rise sharply in the future due to the recent, notable decline in stratospheric ozone, which raises transmitted short-wavelength UV light. We\\\\\\\'ll talk about the epidemiologic characteristics and dose-response relationships of UV-induced skin cancers. Chemical exposure (Polycyclic hydrocarbons from incomplete coal or petroleum distillation or combustion; inorganic arsenic; and photosensitizing compounds like psoralens) is another environmental factor that contributes to the development of skin cancer. Since UV radiation is recognized to be the primary risk factor for skin cancer and may be successfully cured when found early, this trend can be reversed through primary and secondary prevention. Appropriate risk (group) indicators must be utilized to identify those at risk in order to detect skin cancer early. In the future, the science of molecular epidemiology should employ new molecular markers or biomarkers to improve the sensitivity and specificity of early detection efforts (Screening programs).
DOI: 10.22271/foodsci.2024.v5.i2b.168
Pages: 116-122 | Views: 90 | Downloads: 41
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How to cite this article:
Tisha Punjabi, Vaishnavi Singh, Jyoti Rani, Pavneet Kaur. Multiple factors influence skin cancer development: A comprehensive review. J Curr Res Food Sci 2024;5(2):116-122. DOI: 10.22271/foodsci.2024.v5.i2b.168
