Journal of Current Research in Food Science
2025, Vol. 6, Issue 1, Part C
Maturity-onset diabetes of the young (MODY): Pathophysiology and dietary management
Author(s): Sonali Das, Gargi Ckakrabarty, Souvik Chakraborty and Deblina Chatterjee
Abstract: Maturity-onset diabetes of the young (MODY) is a rare, monogenic form of diabetes characterized by autosomal dominant inheritance, early onset, and primary defects in pancreatic β-cell function. Unlike type 1 and type 2 diabetes, MODY arises from mutations in genes such as HNF1A, HNF4A, and GCK, which impair insulin secretion without causing insulin resistance or autoimmune β-cell destruction. Understanding the pathophysiology of MODY is crucial for precise diagnosis and personalized treatment, which often includes tailored dietary strategies and pharmacological interventions based on the genetic subtype. Dietary management, focusing on balanced nutrient intake and controlled carbohydrate consumption, is an essential component of care, aiming to stabilize glycemic control and reduce long-term complications. Integrating genetic knowledge with dietary interventions exemplifies the potential of personalized medicine in optimizing outcomes for MODY patients.
DOI: 10.22271/foodsci.2025.v6.i1c.200
Pages: 185-187 | Views: 175 | Downloads: 79
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How to cite this article:
Sonali Das, Gargi Ckakrabarty, Souvik Chakraborty, Deblina Chatterjee. Maturity-onset diabetes of the young (MODY): Pathophysiology and dietary management. J Curr Res Food Sci 2025;6(1):185-187. DOI: 10.22271/foodsci.2025.v6.i1c.200
